Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Butyl isocyanate | HCID 8110 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Amino-2-chlorobenzene-1-sulfonamide | HCID 12533522 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | HCID 19973469 | HCID 19973469 | — |
Reaction Steps
5,7-Dichloro-4-[4-(methylcarbamoyl)-2-chlorobenzenesulfonimide]-1,4-dihydroquinoline-2-carboxylic acid, methyl ester ##STR39## Dissolve 4-amino-2-chlorobenzenesulfonamide (0.96g, 5mmol) in chlorobenzene (10% solution) and distill the mixture to remove any traces of water. Cool to 100° C. and add n-butyl isocyanate (99mg, 1mmol). Heat to reflux and add, by dropwise addition, oxalyl chloride (1.5mL). Purge with nitrogen at 130°-132° C. for 30 minutes and distill to give 2-chloro-4-isocyanatobenzenesulfonyl isocyanate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05606063 |
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| Source dataset | uspto-grants-1997_02 |
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| ORD ID | ord-81bc4a6927634069912ccbdbe59be8e4 |
|---|
| Source note | uspto-grants-1997_02 |
|---|
