反应详情

温度

40 °C

4.0 g (40 mmol) of hydantoin, 30 ml of acetic acid, and 2.0 ml (40 mmol) of bromine were mixed at room temperature. The reaction mixture was then vigorously stirred at a temperature of 40° C. for 2 hours. The reaction system was then allowed to cool to room temperature. To the reaction system was then added 5.7 g (60 mmol) of phenol. The reaction mixture was then allowed to undergo reaction at a temperature of 100° C. for 6 hours. The resulting precipitate was recovered by filtration, washed with water, and then dried to obtain 4.0 g (yield: 52%) of 5-(p-hydroxyphenyl)hydantoin.

1. temperatureto cool to room temperature
2. customreaction at a temperature of 100° C. for 6 hours
3. filtrationThe resulting precipitate was recovered by filtration
4. washwashed with water
5. customdried