HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → 1-(2-t-Butyldimethylsilyloxyethyl)-5-methylpyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | Ethyl 1-(2-t-butyldimethylsilyloxyethyl)-5-methylpyrazole-3-carboxylate | HCID 22145416 | — |
| Product | 1-(2-t-Butyldimethylsilyloxyethyl)-5-methylpyrazole-3-carboxylic acid | HCID 22145400 | — |
Reaction Steps
The title compound was prepared from ethyl 1-(2-t-butyldimethylsilyloxyethyl)-5-methylpyrazole-3-carboxylate (16.08 g, 51.5 mM) as described in Example 4 Preparation 2 as a white solid (10.5 g, 72%); νmax (KBr) 1688, 1648, 1533 and 1505 cm-1 ; δH (CDCl3) -0.10 (6H, s), 0.81 (9H, s), 2.35 (3H, s), 4.00 (2H, t, J5 Hz), 4.24 (2H, t, J5 Hz),6.60 (1H, s); NH3DCI m/e 285 (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05606051 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-5774b23554dd4040ab0475a7d38361f2 |
| Source note | uspto-grants-1997_02 |