HCID 131719572, compound → HCID 66691394, compound

Participants

Reaction Steps

50 mg of {4(S)-Azido-7(S)-butylcarbamoyl-5(S)-hydroxy-2(S)-isopropyl-8-methyl-1 (R,S)-[4- methoxy-3-(2-methoxymethoxyethyl)-phenyl]-nonyl}-isobutyrate are hydrogenated in 10 ml of methanol in the presence of 50 mg of 10% Pd/C at room temperature and normal pressure. The reaction mixture is filtered and concentrated by evaporation. The residue is purified by FC (2 g of silica gel, dichloromethane/methanol 9:1). The title compound is obtained: Rf (dichloromethane/methanol 9:1)=0.19; HPLC Rt =13.42 minutes; FAB-MS (M+H)+ =509.

Provenance & Evidence