Methyl iodide → 2-Methoxyphenethyl alcohol

Participants

Reaction Steps

35.3 g of caesium carbonate and then a solution of 6.5 ml of methyl iodide in 40 ml of acetone are added to a solution of 10 g of 2-(2-hydroxyphenyl)-ethanol in 200 ml of acetone. The reaction mixture is stirred for 50 minutes at room temperature, filtered and concentrated by evaporation. The residue is partitioned between diethyl ether and water. The organic phases are combined, dried over magnesium sulfate and concentrated by evaporation and the residue is purified by means of FC (dichloromethane/diethyl ether 97:3) to yield the title compound: Rf (dichloromethane/diethyl ether 97:3)=0.34; HPLC Rt =9.31 minutes.

Provenance & Evidence