Hydrochloric Acid → HCID 57480416, compound

Participants

Reaction Conditions

Reaction Steps

30 mg of 5(S)-(tert-butoxycarbonyl) amino-4(S)-hydroxy-2(S)-isopropyl-7(S)-[4-(3-hydroxypropoxy)-3-(3-methoxypropoxy)-benzyl]-8-methyl-nonanoic acid N-(2-morpholin-4-yl-ethyl)amide are dissolved in 1.5 ml of a 4N solution, cooled to 0° C., of hydrochloric acid in dioxane and the solution is stirred further for 10 minutes at 0° C. The reaction mixture is concentrated to dryness by evaporation under reduced pressure at room temperature. The residue is purified by means of FC (5 g of silica gel, dichloromethane/methanol 98:2) to yield the title compound: Rf (dichloromethane/methanol 8:2)=0.20; Rt =10.43 minutes; FAB-MS (M+H)+ =610.

Provenance & Evidence