Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 19972408 | HCID 19972408 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19972667 | HCID 19972667 | — |
Reaction Steps
A mixture of 22.8 g of Intermediate XIX and 6.8 g of sodium azide in 110 ml of dimethylformamide was stirred for 3 hours at 100° C. After cooling to ambient temperature, 130 ml of water and 88 ml of ethanol were added to the reaction mixture. After 1 hour, the crystals were collected by vacuum filtration, washed with water, and desiccated. Yield: 22 g of the title product. A sample recrystallized from ethanol had a melting point of 132°-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05605896 |
|---|
| Source dataset | uspto-grants-1997_02 |
|---|
| ORD ID | ord-d42703f2e7f24ebd8e39c1e80f4b42f8 |
|---|
| Source note | uspto-grants-1997_02 |
|---|
