Methanol → (4-amino-1,1-dioxothiolan-3-yl)-[3-[(4-fluorophenyl)methyl]piperidin-1-yl]methanone

HRID 145233Notes

Reaction equation

HRID 145233 reaction equation
[CH3:36][OH:37].[O:1]=[S:2]1(=[O:32])[CH2:3][CH:4]([C:16](=[O:17])[N:18]2[CH2:19][CH:20]([CH2:24][c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[CH2:21][CH2:22][CH2:23]2)[CH:5]([NH:7][CH:8]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[CH3:15])[CH2:6]1.[OH-:33].[OH-:35].[Pd+2:34]>>[O:1]=[S:2]1(=[O:32])[CH2:3][CH:4]([C:16](=[O:17])[N:18]2[CH2:19][CH:20]([CH2:24][c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[CH2:21][CH2:22][CH2:23]2)[CH:5]([NH2:7])[CH2:6]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 178463375HCID 178463375, compound

Product 1

HCID 178508139(4-amino-1,1-dioxothiolan-3-yl)-[3-[(4-fluorophenyl)methyl]piperidin-1-yl]methanone

Sources & evidence

ORD record
ord-dac17415bdc64590b29c00f6180cc3f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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