3-Methylflavone-8-carboxylic acid → HCID 19972616, compound

HRID 1452335Notes

Reaction equation

HRID 1452335 reaction equation
C([C:4]1[C:13]2[O:12][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:10]([CH3:20])[C:9](=[O:21])[C:8]=2[CH:7]=[CH:6][CH:5]=1)(O)=O.[Cl:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][N:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[O:37][CH3:38])[CH2:27][CH2:26]1.[CH2:39]([OH:41])[CH3:40].C([O:44]CC)C>>[ClH:22].[ClH:22].[CH3:38][O:37][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[N:28]1[CH2:29][CH2:30][N:25]([CH2:24][CH2:23][O:41][C:39]([CH2:40][C:4]2[C:13]3[O:12][C:11]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)=[C:10]([CH3:20])[C:9](=[O:21])[C:8]=3[CH:7]=[CH:6][CH:5]=2)=[O:44])[CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 770163-Methylflavone-8-carboxylic acidHCID 5956731-(2-Chloroethyl)-4-(2-methoxyphenyl)piperazineHCID 21585056Diethyl ether ethanol

Product 1

HCID 19972616HCID 19972616, compound

Procedure

The title compound was prepared by the method described in Example 5, but using Intermediate XLVII in place of 8-carboxy-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran and 1-(2-chloroethyl)-4-(2-methoxyphenyl)-piperazine instead of 1-(3-chloropropyl)-4-(2-methoxyphenyl)piperazine. m.p. 193°-196° C. from ethanol/diethyl ether.

Sources & evidence

ORD record
ord-e32c8a0fcebd4235bb7c259de4195655
Source dataset
uspto-grants-1997_02
Patent number
US05605896

Reaction notes

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