4-Acetoxy-3,5-Di-tert-Butyl-2-(2-Propenyloxy)phenol 4-Acetoxy-3,5-di-tert-butyl-1-(2-propenyloxy)benzene → 4-Acetoxy-3,5-di-tert-butyl-2-(2-propenyl)phenol

Participants

Reaction Steps

Synthesis of 4-Acetoxy-3,5-Di-tert-Butyl-2-(2-Propenyloxy)phenol 4-Acetoxy-3,5-di-tert-butyl-1-(2-propenyloxy)benzene (11.0 g) was dissolved in N,N-dimethylaniline (50 ml) and the solution was refluxed for 18 h under a nitrogen atmosphere. After cooling to room temperature, the reaction solution was concentrated under reduced pressure and purified by silica gel chromatography (15% ethyl acetate in n-hexane) to afford 4-acetoxy-3,5-di-tert-butyl-2-(2propenyl)phenol [8.84 g (yield, 77%)] as a white solid.

Provenance & Evidence