Sodium Hydroxide → HCID 11010263, compound

HRID 1452404Notes

Reaction equation

HRID 1452404 reaction equation
[Si:1]([O:8][C@@H:9]1[CH2:14][CH2:13][C@@H:12]([O:15]C(=O)C)[C@H:11]([CH3:19])[O:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH-].[Na+]>CO.O>[Si:1]([O:8][C@@H:9]1[CH2:14][CH2:13][C@@H:12]([OH:15])[C@H:11]([CH3:19])[O:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 10869950HCID 10869950, compound

Product 1

HCID 11010263HCID 11010263, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of the acetate from step 2 herein (36 mg, 0.13 mmol) in dry MeOH (1.3 ml), at room temperature, was added 1N NaOH (0.14 ml, 1.1 eq.) and the solution was stirred for 45 minutes. It was then poured in H2O and the aqueous phase was extracted 3× with CH2Cl2. The combined organic extracts were dried over MgSO4, the solids were filtered and the solvent evaporated to give 30 mg (96%) of the pure titled alcohol.

Workup

  1. extractionthe aqueous phase was extracted 3× with CH2Cl2
  2. dry with materialThe combined organic extracts were dried over MgSO4
  3. filtrationthe solids were filtered
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-678571a1e1d847faae8b6a290c7ba1ce
Source dataset
uspto-grants-1997_02
Patent number
US05606037

Reaction notes

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