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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1452409Generated: October 26, 2026

3-Methylglutaric anhydride → 4-[N-{(1RS,2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propyl}carbamoyl]-3-methylbutanoic acid

https://huagongshe.com/reaction/1452409

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methylglutaric anhydrideHCID 77828—
Reactant(1RS,2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propylamineHCID 19073559—
Product4-[N-{(1RS,2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propyl}carbamoyl]-3-methylbutanoic acidHCID 19073776—

Reaction Steps

Compounds of Examples 57 to 65 were prepared in the same manner as in Example 56 except that (1RS, 2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propylamine and/or 3-methylglutaric anhydride used as the starting materials in the above reaction were changed to the corresponding amine compounds and/or acid anhydrides.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05606101
Source datasetuspto-grants-1997_02
ORD IDord-04f4750723374f2cb055b3ecba43498f
Source noteuspto-grants-1997_02