反应详情

7-Phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one ( ) was dissolved in 50 mL of MeOH and stirred at room temperature. OXONE™ (13.5 g, 22 mmol) was dissolved in 10 mL of water and added to the stirring reaction. The reaction mixture was stirred for 8 hours, and then evaporated under reduced pressure. The resulting aqueous residue was diluted with 200 mL of water and extracted three times with 100 mL of EtOAc. The combined extracts were dried over MgSO4, and the solvent was removed under reduced pressure to yield an oil which was eluted through silica gel with 1:1 EtOAc/hexanes. Removal of solvent under reduced pressure afforded 1.7 g (5.9 mmol, 59%) of 7-benzenesulfonyl-3,4-dihydro-2H-naphthalen-1-one as an oil. MS: 287 (M+H)+.

1. additionadded to the stirring reaction
2. stirringThe reaction mixture was stirred for 8 hours
3. customevaporated under reduced pressure
4. additionThe resulting aqueous residue was diluted with 200 mL of water
5. extractionextracted three times with 100 mL of EtOAc
6. dry with materialThe combined extracts were dried over MgSO4
7. customthe solvent was removed under reduced pressure
8. customto yield an oil which
9. washwas eluted through silica gel with 1:1 EtOAc/hexanes
10. customRemoval of solvent under reduced pressure