Imidazole → HCID 178511507, compound

Participants

Reaction Steps

The freshly prepared mixture of 1.45 g (5 eq.) triphenylphosphine and 0.28 ml (5 eq.) Br2 in 20 ml of dichloromethane was added to 1 g of the polymer-bound trans-2-(4-amino-cyclohexyl)-ethanol and 0.38 g (5 eq.) 1-H-imidazole. The suspension was shaken for 18 hours, filtered and the resin was washed in sequence with the following solvents (20 ml, twice with each): dichloromethane, methanol, 10% triethylamine in dimethylformamide, methanol, dimethylformamide, tetrahydrofuran, diethylether.

Provenance & Evidence