Water → HCID 10316466, compound

Participants

Reaction Steps

500 mg of 4-[3-hydroxy-5-(4-methoxyphenyl)-1,2,4-triazole-1-yl]-benzenesulfonamide prepared in the above Example 16, was dissolved in 10 ml of DMF and then 1.05 eq of NaH was slowly added thereto. Afterwards 1.5 eq of iodomethane was added to the mixture and then stirred for 3 hours at the same temperature. When the reaction was completed, the resultant was poured into 100 ml of cold water to form precipitate. The precipitate was filtered and then washed with 100 ml of cold ether and 100 ml of cold water (1× each) to give 385 mg (yield 75%) of the titled compound as a white solid.

Provenance & Evidence