Propionic Acid → HCID 57526999, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dichlorohexan-2-one (Intermediate 5) (45.3 mg, 0.27 mmol) and 4-methylbenzenesulfonohydrazide (50 mg, 0.27 mmol) were added to propionic acid (0.5 ml) and then heated to 60° C. for 4 hours. The reaction mixture was then heated to 100° C. for 5 minutes and allowed to cool to room temperature overnight. Hexanes (20 ml) were added and the precipitate was filtered under nitrogen to yield the title compound (39.5 mg).

Provenance & Evidence