Triphenylphosphine → HCID 11325272, compound

Participants

Reaction Steps

(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-(azidomethyl) oxazolidin-2-one (Intermediate 2) (3 g, 8.2 mmol) was dissolved in acetonitrile/water (10:1, 50 ml). Triphenylphosphine (2.6 g, 9.9 mmol) was added and the resulting mixture was stirred over night with evolution of nitrogen. The reaction mixture was applied onto a silica gel column and eluted with acetonitrile/water (15:1 to 5:1) to give the title compound (2.67 g).

Provenance & Evidence