(2R)-Oxiran-2-ylmethyl butanoate → HCID 57526976, compound

Participants

Reaction Steps

N-(3,5-Difluoro-4-thiomorpholin-4-yl-phenyl)-carbamic acid benzyl ester (WO 0232857 A1; WO 0198297 A2) (31.5 g, 86.4 mmol), lithium biS(trimethylsilyl)amide solution (95 ml, 1 M in THF) and (R)-(−)-glycidyl butyrate (14.5 g, 79.7 mmol) were reacted as described for Intermediate 25 to give the crude title compound (19.4 g).

Provenance & Evidence