HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1452576Generated: October 30, 2026
Potassium Phosphate, Dibasic → 1-(2-Fluoro-4-nitro-phenyl)-4-methyl-[1,2,3]-triazole
https://huagongshe.com/reaction/1452576
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Phosphate, Dibasic | HCID 24450 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Reactant | 4-methyl-1H-1,2,3-triazole | HCID 178430918 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-Fluoro-4-nitro-phenyl)-4-methyl-[1,2,3]-triazole | HCID 57526988 | 24% |
Reaction Steps
A mixture of 4-methyl-[1,2,3]-triazole (60 g, 0.72 mol), K2HPO4 (250 g, 1.44 mol) and 3,4-difluoronitrobenzene (80 ml, 0.723 mol) in DMF (3.4 litres) was stirred at 85° C. under N2 for 2.5 days. After removal of DMF in vacuo, the residue was chromatographed on silica gel with 0-5% ethyl acetate in dichloromethane to give the title compound as a light yellow solid (38.3 g, 24%). The other two isomers were also isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07473699B2 |
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| Source dataset | uspto-grants-2009_01 |
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| ORD ID | ord-0a4ccd04f79a4ba5ab04d9f7a8faf7cc |
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| Source note | uspto-grants-2009_01 |
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