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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1452582Generated: October 30, 2026

1,2-Difluoro-4-nitrobenzene → 1-(2-fluoro-4-nitrophenyl)-3-methyl-1H-1,2,4-triazole

https://huagongshe.com/reaction/1452582

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-Difluoro-4-nitrobenzeneHCID 123053—
Reactant1-(2-Fluoro-4-nitro-phenyl)-4-methyl-[1,2,3]-triazoleHCID 57526988—
ReactantHCID 178433329HCID 178433329—
Product1-(2-fluoro-4-nitrophenyl)-3-methyl-1H-1,2,4-triazoleHCID 5752696344.7%

Reaction Steps

3-Methyl-1,2,4-triazole (34.5 g, 0.416 mol) and 3,4-difluoronitrobenzene (46 ml, 0.416 mol) were reacted as described for Intermediate 22. Chromatography on silica gel with 5-50% ethyl acetate in hexanes and recrystallisation from ethyl acetate/hexanes gave the title compound as light yellow crystals (41.3 g), m.p. 113.8° C.-114.3° C. The other two isomers were also isolated.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07473699B2
Source datasetuspto-grants-2009_01
ORD IDord-fb6fdf0fba514b43af022365a87c5dc1
Source noteuspto-grants-2009_01