Water → HCID 10451895, compound

Participants

Reaction Steps

(5R)-3-{4-[4-(tert-Butyl(dimethyl)silyloxymethyl)-1H-imidazol-1-yl]-3-fluorophenyl}-5-[(4-methyl-1,2,3-triazol-1-yl)methyl]oxazolidin-2-one (Intermediate 31) (1.4 g, 2.88 mmol) was dissolved in tetrahydrofuran (15 ml), and tetrabutylammonium fluoride (3.2 ml, 1.0 M solution in THF) was added. The solution was stirred for 2 hours at room temperature and water (50 ml) was added. The precipitate was collected by filtration and purified by chromatography on silica gel with 3-6% methanol in dichloromethane to give the title compound (0.36 g).

Provenance & Evidence