HRID1452585

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OCc1cn(-c2ccc(N3C[C@H](CN=[N+]=[N-])OC3=O)cc2F)cn1

HCID57114338

未命名化合物

结构：Cc1cn(-c2ccc(N3C[C@H](CN)OC3=O)cc2F)nn1

HCID57526957

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCc1cn(-c2ccc(N3C[C@H](CN)OC3=O)cc2F)cn1

HCID57527007

未命名化合物

收率 102.6%

PROCEDURE

实验过程

(5R)-3-{4-[4-(tert-Butyl(dimethyl)silyloxymethyl)-1H-imidazol-1-yl]-3-fluorophenyl}-5-(azidomethyl)oxazolidin-2-one (WO 9928317, WO 9910343, WO 9731917) (2.0 g, 4.17 mmol) was reacted as described for Intermediate 16 to give the title compound (1.8 g) as a solid, which was taken to the next step without further purification.