Thionyl Chloride → HCID 57527001, compound

Participants

Reaction Steps

Thionyl chloride (0.23 ml) was added to a stirred solution of benzyl 4-[4-(aminocarbonyl)-1H-pyrazol-1-yl]-3-fluorophenylcarbamate (Intermediate 40) (0.76 g, 2.14 mmol) in DMF (20 ml) at 0° C. The resulting mixture was warmed to room temperature and stirred for 1 hour. It was quenched with aqueous saturated sodium bicarbonate solution, extracted with ethyl acetate, dried over sodium sulfate and solvent was removed under vacuum to give the title product (0.71 g).

Provenance & Evidence