Tetrahydrofuran → HCID 57526969, compound

Participants

Reaction Steps

Ethyl 1-(4-{[benzyloxycarbonyl]amino}-2-fluorophenyl)-1H-pyrazole-4-carboxylate (J. Med. Chem, 2000, 43, 5, p 953) (1.33 g, 3.45 mmol) was taken up in ethanol/water (1/1, 80 ml), tetrahydrofuran (10 ml) was added, followed by aqueous sodium hydroxide solution (1M, 155 ml) and it was stirred at room temperature for 5 hours. The organic solvents were removed and the aqueous solution was acidified with 1M aqueous hydrochloric acid. The acidic solution was extracted with ethyl acetate, dried over magnesium sulfate and the solvent removed under reduced pressure to give the title product (1.1 g).

Provenance & Evidence