Acetonitrile → HCID 10364220, compound

Participants

Reaction Steps

(5R)-3-[4-(Tetrahydro-2H-thiopyran-4-yl)-3,5-difluorophenyl]-5[(4-methyl-1,2,3-triazol-1-yl)methyl]oxazolidin-2-one (Example 24) (1.0 g, 2.5 mmol) was oxidized with sodium periodate (0.6 g, 2.8 mmol) as described for Intermediates 42 and 43. Reverse Phase chromatography with 10-25% acetonitrile in water containing 0.1% trifluoroacetic acid gave the Z-isomer as the first eluting product (105 mg), followed by elution of the E-isomer (60 mg) of the title compound.

Provenance & Evidence