HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 10069254, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Reactant | HCID 68880499 | HCID 68880499 | — |
| Reactant | HCID 178434708 | HCID 178434708 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 10069254 | HCID 10069254 | 52.1% |
Reaction Steps
(5R)-3-[4-(Tetrahydro-2H-thiopyran-4-yl)-3,5-difluorophenyl]-5-[(hydroxymethyl)methyl]oxazolidin-2-one (Intermediate 47) (0.66 g, 2 mmol), triphenylphosphine (0.786 g, 3 mmol), 5-methyl tetrazole (0.303 g, 3.6 mmol) and diisopropylazodicarboxylate (0.59 ml, 3 mmol) were reacted as described for Example 28. Chromatography on silica gel with 0.2-0.5% methanol in dichloromethane followed by 40% ethyl acetate in hexanes gave the title product (0.412 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07473699B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-fd2e4df91a9247c088f4bb20e78127b0 |
| Source note | uspto-grants-2009_01 |