Diisopropylethylamine → (5R)-3-[3-Fluoro-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-5-[(4-methyl-1,2,3-triazol-1-yl)methyl]oxazolidin-2-one

Participants

Reaction Steps

(5R)-3-[4-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-3-fluorophenyl]-5-[(4-methyl-1H-1,2,3-triazol-1-yl)methyl]-1,3-oxazolidin-2-one (Example 43) (5.13 g, 11.46 mmol) was reacted with diisopropylethylamine (0.40 ml, 2.29 mmol) and 1-chloroethylchloroformate (1.50 ml, 13.76 mmol) as described for Intermediate 53 to give the crude title compound (4.4 g).

Provenance & Evidence