反应详情

The above aldehyde (1.82 mmol) was dissolved in methanol (27 mL), and sodium borohydride (302 mg, 7.98 mmol) was added to this solution with ice-cooling. After this mixture was stirred for 30 min, aqueous ammonium chloride was added here. The resultant mixture was extracted with ethyl acetate, and the organic layer was washed with brine and dried over sodium sulfate. After the sodium sulfate was filtered off, the solvent was distilled off, and the residue was purified with column chromatography (15% ethyl acetate-hexane) to obtain the title compound (617 mg).

1. temperaturecooling
2. extractionThe resultant mixture was extracted with ethyl acetate
3. washthe organic layer was washed with brine
4. dry with materialdried over sodium sulfate
5. filtrationAfter the sodium sulfate was filtered off
6. distillationthe solvent was distilled off
7. customthe residue was purified with column chromatography (15% ethyl acetate-hexane)