Water → HCID 57526792, compound

Participants

Reaction Steps

To a mixed solution of tetrahydrofuran (3 mL) and N,N-dimethylformamide (1 mL) containing tert-butyl (S)-3-[7-[tert-butoxycarbonyl-(4-ethoxyphenyl)amino]-6-(2-methanesulfonyloxyethyl)pyrazolo[1,5-a]pyrimidin-5-ylamino]piperidine-1-carboxylate (0.693 mmol), sodium hydride (with 40% mineral oil added) (55 mg) was added with ice-cooling, and the mixture was stirred for 2 hr. After the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with brine and dried over sodium sulfate. After the sodium sulfate was filtered off, the solvent was distilled off to obtain the title compound.

Provenance & Evidence