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HRID1452679

反应详情

EQUATION

反应方程式

HRID 1452679 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NCCCBr
HCID4460490

tert-butyl N-(3-bromopropyl)carbamate

C8H16BrNO2

结构：CC(=O)Nc1cccc(C2=CCNCC2)c1
HCID21957228

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)Nc1cccc(C2=CCN(CCCNC(=O)OC(C)(C)C)CC2)c1
HCID21957172

1,1-Dimethylethyl N-[3-[4-[3-(acetylamino)phenyl]-3,6-dihydro-1(2H)-pyridinyl]propyl]carbamate

C21H31N3O3

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCCC[N+](CCCC)(CCCC)CCCC.[I-]
催化剂HCID67553

Tetrabutylammonium Iodide

C16H36IN

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The reaction of tert-butyl N-(3-bromopropyl)carbamate and N-[3-(1,2,3,6-tetrahydro-4-pyridinyl)phenyl]acetamide in refluxing dioxane with catalytic Bu4NI and base as described in Scheme A gave tert-butyl 3-(4-[3-(acetylamino)phenyl]-3,6-dihydro-1(2H)-pyridinyl)propylcarbamate. Deprotection of the BOC group using HCl in dioxane followed by basification (pH 11-12) gave the desired product.