Potassium bisulfate → HCID 86604218, compound

Participants

Reaction Steps

8.39 g (17.0 mmol) of tert-butyl-dimethyl-{4-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-silane was dissolved in 70 mL of THF and 25.4 ml (25.4 mmol) of 1M TBAF solution in THF was added at 0° C. The mixture was stirred at room temperature overnight, a 1M KHSO4 solution was added and the product was extracted with ethyl acetate (2×). The organic phase was washed with brine, dried (Na2SO4), filtered and evaporated. Column chromatography on silica gel with n-heptane/ethyl acetate 5:1 as eluent yielded 4-[2,2,2-trifluoro- 1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenol as a yellow liquid, MS: 379 (M−H)−.

Provenance & Evidence