Acetone → HCID 11657313, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (0.23 mmol) of 3-(4-bromo-phenyl)-benzo[d]isothiazol-6-ol (CAS 423159-55-1, prepared as described in WO 2002036584) in 2 ml of acetone were treated with 67 mg (0.22 mmol) of 4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenol (example 6), 76 mg (0.2 mmol) of Cs2CO3 and 8 mg (0.05 mmol) of potassium iodide. The reaction mixture was stirred at ambient temperature for 2.5 d, at 45° C. for 4 h, and then was diluted with dichloromethane. The organic phase was washed with water and brine, dried (Na2SO4) and evaporated. The crude product was purified by column chromatography on silica gel to yield 40 mg (28%) 2-(4-{3-[3-(4-bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-propoxy}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol as a colorless solid, MS: 604 (M−H, 1Br)−.

Provenance & Evidence