Lithium Hydroxide → HCID 11699185, compound

Participants

Reaction Steps

40 mg (0.08 mmol) of rac (4-{1-phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester (example 9) in 1 mL of THF were treated with 0.76 mL of 1M LiOH at room temperature for 2 h. 1M KHSO4 solution was added, the phases were separated, and the inorganic one was extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated. The crude product was purified by column chromatography to give 29 mg (74%) of rac (4-{1-phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid as a colorless oil, MS: 513 (M−H)−.

Provenance & Evidence