Lithium Hydroxide → HCID 11669619, compound

Participants

Reaction Steps

94 mg (0.2 mmol) of 4-{3-[2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid methyl ester (example 19) in 2 mL of THF were treated with 2 mL of 1M LiOH at room temperature overnight. 1M KHSO4 solution was added, the phases were separated, and the inorganic one was extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated. The crude product was purified by column chromatography with CH2Cl2/MeOH 95:5 to give 60 mg (65%) 4-{3-[2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid as a light yellow solid, MS: 451 (M−H)−.

Provenance & Evidence