Methyl 3-Hydroxyphenylacetate → Rac (3-{1-phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester

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Reaction Steps

In analogy to example 9.2, from rac 1-phenyl-2-{3-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-ethanol (example 9.1) and (3-hydroxy-phenyl)-acetic acid methyl ester was prepared via rac [3-(1-phenyl-2-{3-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-ethoxy)-phenyl]-acetic acid methyl ester, which was deprotected according to example 13.2, to give rac (3-{1-phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester as a colorless oil, MS: 527 (M−H)−.

Provenance & Evidence