反应详情

温度

0 °C

Acetyl chloride (6 mmol) was added dropwise to the mixture of 2-iodoaniline (5 mmol) and sodium hydroxide (13 mmol) in THF/H2O (1/1, 4 mL). Stirred the mixture at 0° C. for 2 h, and then at room temperature for overnight. The mixture was diluted with 10 mL water and extracted with diethyl ether 3 times. The combined organic layer was washed with water 3 times and brine. Dried over sodium sulfate, filtered, and removed solvent. The residue was then purified by column chromatography afforded white solid of 2-iodoacetanilide 68% yield. NMR

1. waitat room temperature for overnight
2. extractionextracted with diethyl ether 3 times
3. washThe combined organic layer was washed with water 3 times and brine
4. dry with materialDried over sodium sulfate
5. filtrationfiltered
6. customremoved solvent
7. customThe residue was then purified by column chromatography