Methyl 4-iodobenzoate → HCID 25159790, compound

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Reaction Steps

The general procedure was used to convert methyl 4-iodobenzoate and N-(2-ethynylphenyl)acetamide to the title product. Purification by flash chromatography gave the analytically pure product as a white solid, 59% yield. 1H NMR (300 MHz, DMSO) δ 8.20-8.17 (d, J=8.2, 1H), 8.06-8.04 (d, J=8.2, 2H), 7.70-7.67 (d, J=8.3, 2H), 7.66-7.64 (d, J=7.7, 1H), 7.41-7.28 (m, 2H), 6.91 (s, 1H), 3.89 (s, 3H), 2.20 (s, 3H). 13C NMR (75 MHz, DMSO) δ 171.63, 166.71, 139.56, 139.00, 138.06, 130.21, 129.96, 129.78, 129.56, 126.06, 124.37, 124.33, 121.81, 116.10, 113.06, 53.12, 28.53. Anal. Calcd. for C18H15NO3: C, 73.71; H, 5.15; N, 4.78. Found C, 73.50; H, 5.21; N, 4.54.

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