Dimethyl Sulfoxide → HCID 178522522, compound

Participants

Reaction Steps

A mixture of 4-bromo-5-pyridin-2-yl-2H-pyrazol-3-ylamine hydrobromide salt (193 mg, 0.60 mmol), furan-2-carbonyl isothiocyanate (0.07 mL), pyridine (0.1 mL), and DMSO (2 mL) was placed in a Smith process vial. The reaction was run in a Personal Chemistry SmithCreator microwave at 160° C. for five minutes. The reaction mixture was then added to an excess of water and the resulting precipitate was filtered. Purification by preparative HPLC afforded 10 mg of furan-2-carboxylic acid (3-pyridin-2-yl-1H-pyrazolo[3,4-d]thiazol-5-yl)-amide as a white solid. 1H-NMR (d6-DMSO) δ: 8.60 (dd, 1H), 7.92 (m, 2H), 7.80 (d, 1H), 7.46 (d, 1H), 7.26 (m, 2H), 6.60 (dd, 1H); HPLC/MS m/z: 312 [MH]+.

Provenance & Evidence