Theophylline → HCID 69028523, compound

Participants

Reaction Steps

A mixture of 0.59 g (3.26 mmole) of theophylline, 1.5 g (6,52 mmole) of 2-(4-nitrophenyl)ethyl bromide, 0.13 g (3.26 mmole) of NaOH pellets in 4 ml of water and 8 ml of isopropanol is heated to reflux for 24 hours. After returning to 23° C., the insoluble portion is filtered and the filtrate is extracted with 25 ml of CH2Cl2. The organic phase is washed with 10 ml of water followed by 10 ml of brine. After drying over sodium sulphate, filtration and concentration to dryness, the residue is purified on a silica column (eluent: CH2Cl2/MeOH: 95/5). A white solid is obtained with a yield of 50%.

Provenance & Evidence