Benzoyl chloride → N-[5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazol-3-yl)benzamide

HRID 1452873Notes

Reaction equation

HRID 1452873 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][S:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[S:21]([CH3:24])(=[O:23])=[O:22])(=[O:14])=[O:13])[CH:9]=2)[NH:4][N:3]=1.[C:25](Cl)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>N1C=CC=CC=1>[CH3:24][S:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([NH:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][N:3]=[C:2]2[NH:1][C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)(=[O:13])=[O:14])(=[O:23])=[O:22]

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 22567244HCID 22567244, compound

Product 1

HCID 22567139N-[5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazol-3-yl)benzamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-[5-(2-Methylsulfonylbenzenesulfonylamino)-1H-indazol-3-yl]benzamide can be obtained as described in Example 28 from 0.5 g of N-(3-amino-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide, 3 ml of pyridine and 0.158 ml of benzoyl chloride. 435 mg of N-[5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazol-3-yl)benzamide are thus obtained in the form of a pink solid which decomposes at approximately 200° C. (analysis C21H18N4O5S2.0.22CH2Cl2 % calculated C, 53.60; H, 3.86; N, 11.91; O, 17.00; S, 13.63. % found C, 53.59; H, 3.89; N, 12.10; S, 13.53).

Sources & evidence

ORD record
ord-f536f3690cc5481ea30aeb3ef69fe424
Source dataset
uspto-grants-2009_01
Patent number
US07473701B2

Reaction notes

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