HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-[3-(1H-benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Methanesulfonylbenzene-1-sulfonyl chloride | HCID 2735178 | — |
| Reactant | 3-(1H-benzimidazol-2-yl)-5-amino-1-{[2-(trimethylsilyl)ethoxy]methyl}indazole | HCID 136336345 | — |
| Solvent | Cyclohexane ethylacetate | HCID 21867204 | — |
| Product | N-[3-(1H-benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide | HCID 135621934 | 94% |
Reaction Steps
N-[3-(1H-Benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 2 from 130 mg of 3-(1H-benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-ylamine, 5 ml of pyridine and 87 mg of 2-methylsulfonylbenzenesulfonyl chloride. 192 mg of N-[3-(1H-benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide are thus obtained in the form of an orange lac (Rf=0.53, silica gel thin layer chromatography, eluent: cyclohexane/ethyl acetate (50/50 by volume), mass analysis: Cl: m/z 598 (M+H)+.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07473701B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-fbc690c71eed401c89c826aefc320599 |
| Source note | uspto-grants-2009_01 |