2-Thiophenecarbonyl chloride → 6-{[(3-Fluoro-4-morpholin-4-yl-phenyl)-(thiophene-2-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

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Reaction Steps

To a stirring solution of 6-[(3-Fluoro-4-morpholin-4-yl-phenylamino)-methyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester prepared above (500 mg, 1.28 mmol) in 10 mL of DCE at room temperature was added DIEA (0.33 mL, 1.92 mmol) and 2-thiophenecarbonylchloride (0.21 mL, 1.92 mmol). After 2 hours, saturated NaHCO3 was added, and the mixture was extracted with CH2Cl2. The combined extracts were dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The resulting crude material was taken up in 50% EtOAc/hexanes and the white solids were filtered off. The remaining filtrate was concentrated under reduce pressure to yield 640 mg of the desired product. 400 MHz 1H NMR (CDCl3) δ 7.26-7.28 (m, 1H), 6.83-7.15 (m, 4H), 6.76-6.78 (m, 1H), 3.79-3.85 (m, 5H), 3.54-3.59 (m, 1H), 3.44 (d, J=11.0 Hz, 1H), 3.39 (d, J=11.0 Hz, 1H), 3.21-3.26 (m, 2H), 3.08-3.10 (m, 4H), 1.36-1.38 (m, 11H), 0.81-0.86 (m, 1H); MS M+1)

Provenance & Evidence