(2-(Isopropylamino)thiazolo[4,5-c]pyridin-6-yl)methanol → 2-(Isopropylamino)thiazolo[4,5-c]pyridine-6-carbaldehyde

Participants

Reaction Steps

To a solution of (2-(isopropylamino)thiazolo[4,5-c]pyridin-6-yl)methanol (0.1063 g, 0.476 mmol, 1.0 eq.) in THF (5 mL) under nitrogen was added MnO2 (0.6441 g, 7.4 mmol, 15.6 eq.). After 1.75 hr, the reaction solution was filtered through Celite and rinsed with THF. The filtrate was concentrated in vacuo to give crude 2-(isopropylamino)thiazolo[4,5-c]pyridine-6-carbaldehyde as a yellow solid (0.1711 g). This material was used without further purification.

Provenance & Evidence