(2-(Sec-butylamino)thiazolo[5,4-b]pyridin-5-yl)methanol → 2-(Sec-butylamino)thiazolo[5,4-b]pyridine-5-carbaldehyde

Participants

Reaction Steps

To a solution of (2-(sec-butylamino)thiazolo[5,4-b]pyridin-5-yl)methanol (0.1155 g, 0.487 mmol, 1.0 eq.) in THF (3.5 mL) under nitrogen was added MnO2 (0.6357 g, 7.3 mmol, 15.0 eq.). After 1 hr, the reaction solution was filtered through Celite and rinsed with THF. The filtrate was concentrated in vacuo to give crude 2-(sec-butylamino)thiazolo[5,4-b]pyridine-5-carbaldehyde as a colorless oil which was carried to the next step without purification.

Provenance & Evidence