Water → HCID 57527220, compound

Participants

Reaction Steps

A solution of N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)thiazolo[5,4-b]pyridine-2-yl)benzamide (0.36 g, 0.838 mmol, 1.0 eq.) in 70% aqueous H2SO4 (4.2 mL) was heated at 105° C. for 2 h. After cooling to room temperature, the reaction mixture was added to water. At 0° C., 30% aqueous NaOH followed by solid NaOH were added until pH ˜13 by litmus paper. The precipitate was washed with water and dried to give 5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)thiazolo[5,4-b]pyridine-2-amine as a tan solid (0.1493 g, 55% yield).

Provenance & Evidence