反应详情

To a mixture of 440.4 mg (2.0 mmol) of 2,2′-bisfluorobenzhydrol and 1.04 g (12.0 mmol) of activated manganese oxide was added 10 ml of benzene. The resultant was refluxed for 2 hours. The reaction mixture was cooled to room temperature, and filtrated with celite. The filtrate was concentrated and purified by column chromatography on silica gel (ethyl acetate:hexane=1:5) to give 360 mg (yield: 82%) of the title compound in the form of a yellow solution.

1. temperatureThe resultant was refluxed for 2 hours
2. filtrationfiltrated with celite
3. concentrationThe filtrate was concentrated
4. custompurified by column chromatography on silica gel (ethyl acetate:hexane=1:5)