Acetophenone → 1-Phenylethanol, (R)-

Participants

Reaction Steps

Into a pressure-resistant vessel was placed 11.1 mg (0.012 mmol) of RuCl2(DPEphos){(S,S)-DPEN} synthesized in Example 4, and then thereto were added 48 μl (0.024 mmol) of a 0.5M solution of potassium hydroxide in 2-propanol and 3.3 ml of 2-propanol. Under an argon atmosphere, the solution was stirred for 30 minutes. Thereafter, 350 μl (3.0 mmol) of acetophenone was added thereto, and then the solution was stirred under hydrogen atmosphere of 0.8 MPa (8 atm) for 4 hours to give (1R)-1-phenylethanol, which is an alcohol reductant of acetophenone, in a GC yield of not less than 99% and an asymmetric yield of 91% ee.

Provenance & Evidence