Methyl iodide → 2-(4-Bromo-2-fluorophenyl)propanenitrile

HRID 1453147Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]#[N:13])CC[CH2:9]2)=[C:4]([F:14])[CH:3]=1.IC>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:9])[C:12]#[N:13])=[C:4]([F:14])[CH:3]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 587626531-(4-Bromo-2-fluorophenyl)cyclobutanecarbonitrile

Product 1

HCID 587623452-(4-Bromo-2-fluorophenyl)propanenitrile

Procedure

The title compound was prepared analogously to 1-(4-Bromo-2-fluoro-phenyl)-cyclobutanecarbonitrile in step 2 of example A(236) substituting iodomethane in place of 1,3-dibromopropane. MS (APCI): 253 (M+H+), 255 (M+2+H+).

Sources & evidence

ORD record: ord-051b271b2bb842feb160ed43e0796ada
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07473790B2

Reaction notes

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