HCID 58762526, compound → HCID 58762726, compound

HRID 1453256Notes

Reaction equation

HRID 1453256 reaction equation
Cl[C:2]1[C:3](=[O:15])[O:4][C:5]([CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)([CH3:9])[CH2:6][C:7]=1[OH:8].[CH3:16][C:17]1[CH:22]=[C:21]([CH3:23])[N:20]2[N:24]=[C:25]([SH:27])[N:26]=[C:19]2[N:18]=1>>[CH:10]1([C:5]2([CH3:9])[O:4][C:3](=[O:15])[C:2]([S:27][C:25]3[N:26]=[C:19]4[N:18]=[C:17]([CH3:16])[CH:22]=[C:21]([CH3:23])[N:20]4[N:24]=3)=[C:7]([OH:8])[CH2:6]2)[CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 58762526HCID 58762526, compoundHCID 178426287HCID 178426287, compound

Product 1

HCID 58762726HCID 58762726, compound

Procedure

The title compound was prepared from 3-Chloro-6-cyclopentyl-4-hydroxy-6-methyl-5,6-dihydro-pyran-2-one (described in Step 2 below) and 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol using the coupling method described in Example C(4). 1H NMR (CDCl3): δ 1.54 (s, 3H), 1.55-2.32 (br m, 9H), 2.59 (m 1H), 2.64 (s, 3H), 2.71 (s, 3H), 2.96 (m, 1H), 6.77 (s, 1H). ESIMS: MH+ 375.10, MH− 373.10.

Sources & evidence

ORD record
ord-04c78e4c91a2419ab30b88f01a78496a
Source dataset
uspto-grants-2009_01
Patent number
US07473790B2

Reaction notes

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