4-Bromo-2-chloro-1-isopropoxybenzene → 3-(3-Chloro-4-isopropoxy-phenyl)-1-cyclopentyl-propan-1-one

HRID 1453262Notes

Reaction equation

HRID 1453262 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]([CH3:11])[CH3:10])=[C:4]([Cl:12])[CH:3]=1.C1([CH2:19][CH2:20][C:21]([CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:22])CCCCC=1>>[Cl:12][C:4]1[CH:3]=[C:2]([CH2:19][CH2:20][C:21]([CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:22])[CH:7]=[CH:6][C:5]=1[O:8][CH:9]([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 219385904-Bromo-2-chloro-1-isopropoxybenzeneHCID 58762453HCID 58762453, compound

Product 1

HCID 219385323-(3-Chloro-4-isopropoxy-phenyl)-1-cyclopentyl-propan-1-one

Procedure

The ketone intermediate, was prepared analogously to Example A(27), where 4-Bromo-2-chloro-1-isopropoxy-benzene (from Step 3 below) was substituted in place of 3-Cyclohex-1-enyl-1-cyclopentyl-propan-1-one in Step 1 of that example.

Sources & evidence

ORD record
ord-54dc184426314d538e0cc840602dba78
Source dataset
uspto-grants-2009_01
Patent number
US07473790B2

Reaction notes

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